Synthesis and Analgesic activity of Methylphenyl Semicarbazone derivatives
نویسندگان
چکیده
In the present study a series of methylphenylsemicarbazones was synthesized and evaluated for their analgesic activities by writhing, hot plate and formalin induced paw licking animal model. Most of the compounds were found to be more or comparable potent than the reference standard drug in all the three animal models. Based on the results of analgesic study It was found that chloro substitution in the aldehydic moiety and amino substitution in acetophenic moiety of chalcone exhibited better activity. Lengthening of carbon chain also favor analgesic activity.
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